全文获取类型
收费全文 | 25850篇 |
免费 | 4605篇 |
国内免费 | 3113篇 |
专业分类
化学 | 18754篇 |
晶体学 | 333篇 |
力学 | 1535篇 |
综合类 | 201篇 |
数学 | 2619篇 |
物理学 | 10126篇 |
出版年
2024年 | 19篇 |
2023年 | 520篇 |
2022年 | 619篇 |
2021年 | 902篇 |
2020年 | 1087篇 |
2019年 | 1094篇 |
2018年 | 941篇 |
2017年 | 824篇 |
2016年 | 1317篇 |
2015年 | 1251篇 |
2014年 | 1485篇 |
2013年 | 1954篇 |
2012年 | 2369篇 |
2011年 | 2337篇 |
2010年 | 1703篇 |
2009年 | 1636篇 |
2008年 | 1744篇 |
2007年 | 1563篇 |
2006年 | 1485篇 |
2005年 | 1298篇 |
2004年 | 974篇 |
2003年 | 819篇 |
2002年 | 867篇 |
2001年 | 620篇 |
2000年 | 500篇 |
1999年 | 503篇 |
1998年 | 415篇 |
1997年 | 401篇 |
1996年 | 365篇 |
1995年 | 319篇 |
1994年 | 266篇 |
1993年 | 205篇 |
1992年 | 190篇 |
1991年 | 181篇 |
1990年 | 142篇 |
1989年 | 121篇 |
1988年 | 90篇 |
1987年 | 59篇 |
1986年 | 77篇 |
1985年 | 62篇 |
1984年 | 38篇 |
1983年 | 31篇 |
1982年 | 29篇 |
1981年 | 23篇 |
1980年 | 18篇 |
1975年 | 13篇 |
1974年 | 8篇 |
1973年 | 9篇 |
1972年 | 9篇 |
1965年 | 7篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Li Ma Wei Zhang Mingxia Hou Dong Li Fengjuan Liu Xi Du Peng Jiang Zongkui Wang Rong Zhang Haijun Cao Shengliang Ye Changqing Li 《Biomedical chromatography : BMC》2019,33(4)
Intravenous immunoglobulin (IVIg) is increasingly used for the treatment of autoimmune and systemic inflammatory diseases with both licensed and off‐label indications. Recent studies indicated that IVIg‐mediated immunomodulation and anti‐inflammation are closely associated with the IgG sialylation, especially with IgG crystallizable fragment (Fc) sialylation. The sialic acid levels of the IgG molecules and Fc fragments in 12 IVIg preparations from six Chinese manufacturers were evaluated. The Fc fragments were derived from the papain digestion of IVIg, followed by affinity and size exclusion chromatography. The sialic acid levels in Fc fragments and IVIg preparations were determined by high‐performance liquid chromatography with fluorescence detection, after the sialic acid residues were released from the proteins. The results showed that the sialic acid levels in Chinese IVIg preparations ranged from 0.875 (mol/mol IgG) to 1.085 (mol/mol IgG), and the sialic acid levels in Fc fragments were from 0.321 (mol/mol Fc) to 0.361 (mol/mol Fc). Furthermore, the sialic acid levels of IVIg preparations and Fc fragments from different Chinese manufactures were significantly different. These findings will contribute to an increased understanding of Chinese IVIg preparations and the relationship between the sialic acid levels in IVIg preparations and their clinical efficacy in future clinical studies. 相似文献
992.
Iseul Jeong Chae Bin Kim Dong‐Gue Kang Kwang‐Un Jeong Se Gyu Jang Nam‐Ho You Seokhoon Ahn Dai‐Soo Lee Munju Goh 《Journal of polymer science. Part A, Polymer chemistry》2019,57(6):708-715
To address tremendous needs for developing efficiently heat dissipating materials with lightweights, a series of liquid crystalline epoxy resins (LCEs) are designed and synthesized as thermally conductive matrix. All prepared LCEs possess epoxies at the molecular side positions and cyanobiphenyl mesogenic end groups. Based on several experimental results such as differential scanning calorimetry, polarized optical microscopy, and X‐ray diffraction, it is found that the LCEs exhibited liquid crystalline mesophases. When LCE is cured with a diamine crosslinker, the cured LCE maintains the oriented LC domain formed in the uncured state, ascribing to a presence of dipole–diploe and π–π interactions between cyanobiphenyl mesogenic end groups. Due to the anisotropic molecular orientation, the cured LCE exhibits a high thermal conductivity of 0.46 W m?1 K?1, which is higher than those of commercially available crystalline or amorphous epoxy resins. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019 , 57, 708–715 相似文献
993.
Feipeng Liu Zhe Dong Jianchun Wang Guangbin Dong 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(7):2166-2170
To show the synthetic utility of palladium/norbornene (Pd/NBE) cooperative catalysis, here we report concise syntheses of indenone‐based natural products, pauciflorol F and acredinone A, which are enabled by direct annulation between aryl iodides and unsaturated carboxylic acid anhydrides. Compared to the previous indenone‐preparation approaches, this method allows simple aryl iodides to be used as substrates with complete control of the regioselectivity. The total synthesis of acredinone A features two different Pd/NBE‐catalyzed ortho acylation reactions for constructing penta‐substituted arene cores, including the development of a new ortho acylation/ipso borylation. 相似文献
994.
Applied Biochemistry and Biotechnology - Pectin, as one of the most widely used functional polysaccharide, can be abundantly extracted from apple pomace which is the main by-product of apple juice... 相似文献
995.
Nd3+:YCOB单晶是在激光调制技术上具有重要应用价值的自倍频光学材料.采用高温固相反应合成Nd3+∶YCOB多晶粉体,再通过垂直区熔处理制备出高纯度Nd3+∶YCOB晶粒料,采用坩埚下降法生长出1mol;、2mol;和5mo1; Nd3+掺杂比例的系列Nd3+∶ YCOB单晶.测试表征了所生长单晶试样的光谱性能,包括吸收光谱、荧光光谱和荧光衰减时间.在808 nm红外光源激发下,Nd3+∶YCOB单晶显示出中心波长1064 nm的强荧光发射,其荧光寿命为157~162μs,证实1064 nm强荧光发射随Nd3+掺杂浓度加大而明显增强. 相似文献
996.
Metabolite identification of the antimalarial piperaquine in vivo using liquid chromatography–high‐resolution mass spectrometry in combination with multiple data‐mining tools in tandem 下载免费PDF全文
Aijuan Yang Meitong Zang Huixiang Liu Peihong Fan Jie Xing 《Biomedical chromatography : BMC》2016,30(8):1324-1330
Artemisinin‐based combination therapy is widely used for the treatment of uncomplicated Plasmodium falciparum malaria, and piperaquine (PQ) is one of important partner drugs. The pharmacokinetics of PQ is characterized by a low clearance and a large volume of distribution; however, metabolism of PQ has not been thoroughly investigated. In this work, the metabolite profiling of PQ in human and rat was studied using liquid chromatography tandem high‐resolution LTQ‐Orbitrap mass spectrometry (HRMS). The biological samples were pretreated by solid‐phase extraction. Data processes were carried out using multiple data‐mining techniques in tandem, i.e., isotope pattern filter followed by mass defect filter. A total of six metabolites (M1–M6) were identified for PQ in human (plasma and urine) and rat (plasma, urine and bile). Three reported metabolites were also found in this study, which included N‐oxidation (M1, M2) and carboxylic products (M3). The subsequent N‐oxidation of M3 resulted in a new metabolite M4 detected in urine and bile samples. A new metabolic pathway N‐dealkylation was found for PQ in human and rat, leading to two new metabolites (M5 and M6). This study demonstrated that LC‐HRMSn in combination with multiple data‐mining techniques in tandem can be a valuable analytical strategy for rapid metabolite profiling of drugs. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
997.
998.
999.
1000.
Dr. Steffen Bähring Dr. Luis Martín‐Gomis Gunnar Olsen Prof. Dr. Kent A. Nielsen Dr. Dong Sub Kim Dr. Troels Duedal Prof. Dr. Ángela Sastre‐Santos Prof. Dr. Jan O. Jeppesen Prof. Dr. Jonathan L. Sessler 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(6):1958-1967
Supramolecular polymers are a class of macromolecules stabilized by weak non‐covalent interactions. These self‐assembled aggregates typically undergo stimuli‐induced reversible assembly and disassembly. They thus hold great promise as so‐called functional materials. In this work, we present the design, synthesis, and responsive behavior of a short supramolecular oligomeric system based on two hetero‐complementary subunits. These “monomers” consist of a tetrathiafulvalene‐functionalized calix[4]pyrrole (TTF‐C[4]P) and a glycol diester‐linked bis‐2,5,7‐trinitrodicyanomethylenefluorene‐4‐carboxylate (TNDCF), respectively. We show that when mixed in organic solvents, such as CHCl3, CH2ClCH2Cl, and methylcyclohexane, supramolecular aggregation takes place to produce short oligomers stabilized by hydrogen bonding and donor–acceptor charge‐transfer (CT) interactions. The self‐associated materials were characterized by 1H NMR and UV/Vis/NIR absorption spectroscopy, as well as by concentration‐ and temperature‐dependent absorption spectroscopy and dynamic light scattering (DLS) analyses of both the monomeric and oligomerized species. The self‐associated system produced from TTF‐C[4]P and TNDCF exhibits a concentration‐dependent aggregation behavior typical of supramolecular polymers. Further support for the proposed self‐assembly came from theoretical calculations. The fluorescence emitting properties of TNDCF are quenched under conditions that promote the formation of supramolecular aggregates containing TTF‐C[4]P and TNDCF. This quenching effect has been utilized as a probe for the detection of substrates in the form of anions (i.e., chloride) and nitroaromatic explosives (i.e., 1,3,5‐trinitrobenzene). Specifically, the addition of these substrates to mixtures of TTF‐C[4]P and TNDCF produced a fluorescence “turn‐on” response. 相似文献